منابع مشابه
Competition driven cancer immunoediting
It is a well-established fact that in an actively proliferating state tumors up-regulate glucose consumption to meet increasing energy demands by switching to glycolysis. What is often neglected is that actively proliferating cells of the immune system also switch to glycolysis and thus also have increased energy demands. Moreover, while cancer cells can revert back to aerobic metabolism, rapid...
متن کاملImaging, Diagnosis, Prognosis NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting
Purpose: NKG2D (natural killer group 2, member D) binds to cellular ligands of the MIC and ULBP/RAET family. These ligands have restricted expression in normal tissue, but are frequently expressed on primary tumors. The role of NKG2D ligands is thought to be important in carcinogenesis but its prognostic effect has not been investigated in such a large cohort. Experimental Design: In our study,...
متن کاملNKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting.
PURPOSE NKG2D (natural killer group 2, member D) binds to cellular ligands of the MIC and ULBP/RAET family. These ligands have restricted expression in normal tissue, but are frequently expressed on primary tumors. The role of NKG2D ligands is thought to be important in carcinogenesis but its prognostic effect has not been investigated in such a large cohort. EXPERIMENTAL DESIGN In our study,...
متن کاملHypoploidy defines patients with poor prognosis in breast cancer.
The clinicopathological features currently used in breast cancer prognosis often fail to characterize the clinical heterogeneity of the disease accurately. Our study is aimed to investigate the predictive value of DNA flow cytometry in breast cancer. Previously untreated breast carcinoma samples (584) were snap frozen for flow-cytometry. Tumors were classified into three DNA index (DI) categori...
متن کاملTumor immunoediting by NKp46.
NK cells interact with a wide variety of hazardous cells including pathogen-infected and tumor cells. NKp46 is a specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands. It was recently shown that NKp46 plays a significant role in the in vivo eradication of tumor cells; however, the role played by NKp46 in vivo with regard to tumor development is s...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2019
ISSN: 1759-4774,1759-4782
DOI: 10.1038/s41571-019-0205-5